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Background <p>Skin rejuvenation requires a&#xa0;combination of different treatment modalities, including lasers, intense pulsed light (IPL), radiofrequency, high-intensity focused ultrasound (HIFU), botulinum toxin, and fillers. A&#xa0;combined approach is considered optimal; however, same-day combination treatments are generally avoided, and laser treatments are usually performed prior to injection of fillers or toxin due to concerns that light-based energy may inactivate or degrade these substances.</p> Objective <p>The aim of this publication is to provide an overview of the literature on the use of combination therapies and the resulting treatment recommendations.</p> Methods <p>The literature review identified numerous studies on combination therapies in which lasers and energy-based devices (EBDs) were applied on the same day as injections of botulinum toxin&#xa0;A.</p> Conclusion <p>The identified studies consistently reported clinical improvement and no reduction in the efficacy of botulinum toxin&#xa0;A when administered in close temporal proximity, except in the case of fractional radiofrequency microneedling and HIFU.</p>

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Botulinumtoxin A in zeitgleicher Kombination mit Lasern und EBD („energy-based devices“)

  • 期刊论文

  • 发表日期：

    2026年1月16日

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  • Klaus Fritz,
  • Carmen Salavastru,
  • Seher Eren,
  • George Sorin Tiplica

摘要

Background

Skin rejuvenation requires a combination of different treatment modalities, including lasers, intense pulsed light (IPL), radiofrequency, high-intensity focused ultrasound (HIFU), botulinum toxin, and fillers. A combined approach is considered optimal; however, same-day combination treatments are generally avoided, and laser treatments are usually performed prior to injection of fillers or toxin due to concerns that light-based energy may inactivate or degrade these substances.

Objective

The aim of this publication is to provide an overview of the literature on the use of combination therapies and the resulting treatment recommendations.

Methods

The literature review identified numerous studies on combination therapies in which lasers and energy-based devices (EBDs) were applied on the same day as injections of botulinum toxin A.

Conclusion

The identified studies consistently reported clinical improvement and no reduction in the efficacy of botulinum toxin A when administered in close temporal proximity, except in the case of fractional radiofrequency microneedling and HIFU.