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<p>Systemic sclerosis (SSc) is a&#xa0;rare autoimmune connective tissue disease within the spectrum of rheumatologic disorders. It is characterized by a&#xa0;combination of vasculopathy and inflammatory fibrosis affecting the skin and various internal organs. The disease presents with heterogeneous manifestations, which can complicate diagnosis and must be carefully considered during both monitoring and treatment. In recent decades, advances in research have expanded the range of therapeutic options available for SSc. Treatment strategies need to be tailored individually, depending on the specific clinical manifestations in each patient. The aim of this article is to provide an overview of the diverse disease manifestations and current treatment approaches in SSc. For optimal patient care, close collaboration between rheumatologists, pneumologists, gastroenterologists, cardiologists, nephrologists and general practitioners is essential.</p>

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Systemische Sklerose

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年12月11日

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  • Caroline Evers,
  • Jörg Distler,
  • Oliver Distler

摘要

Systemic sclerosis (SSc) is a rare autoimmune connective tissue disease within the spectrum of rheumatologic disorders. It is characterized by a combination of vasculopathy and inflammatory fibrosis affecting the skin and various internal organs. The disease presents with heterogeneous manifestations, which can complicate diagnosis and must be carefully considered during both monitoring and treatment. In recent decades, advances in research have expanded the range of therapeutic options available for SSc. Treatment strategies need to be tailored individually, depending on the specific clinical manifestations in each patient. The aim of this article is to provide an overview of the diverse disease manifestations and current treatment approaches in SSc. For optimal patient care, close collaboration between rheumatologists, pneumologists, gastroenterologists, cardiologists, nephrologists and general practitioners is essential.