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<p>We report the case of a&#xa0;22-year-old man who developed multiple flesh-colored papules during antiepileptic treatment with lamotrigine. Histopathological examination confirmed the diagnosis of lichen nitidus, showing a&#xa0;sharply demarcated lymphohistiocytic infiltrate in a&#xa0;typical “ball-and-claw” configuration. Despite discontinuation of lamotrigine, the lesions persisted, while topical corticosteroid therapy resulted in moderate improvement. This case highlights a&#xa0;rare possible association between lamotrigine and lichen nitidus and contributes to the discussion of drug-induced lichenoid dermatoses.</p>

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Lichen nitidus bei einem jungen männlichen Patienten unter antiepileptischer Therapie

  • 期刊论文

  • 发表日期：

    2025年12月3日

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  • Nawa Arif,
  • Annika Vogt,
  • Kamran Ghoreschi,
  • Alexander Nast

摘要

We report the case of a 22-year-old man who developed multiple flesh-colored papules during antiepileptic treatment with lamotrigine. Histopathological examination confirmed the diagnosis of lichen nitidus, showing a sharply demarcated lymphohistiocytic infiltrate in a typical “ball-and-claw” configuration. Despite discontinuation of lamotrigine, the lesions persisted, while topical corticosteroid therapy resulted in moderate improvement. This case highlights a rare possible association between lamotrigine and lichen nitidus and contributes to the discussion of drug-induced lichenoid dermatoses.