Background <p>The number of patients with keratinocyte tumors is steadily increasing. In addition, personnel and procedural costs for surgical treatment are also rising.</p> Objectives <p>How suitable are modern, noninvasive dermatological imaging devices for improving the efficiency of tumor diagnostics and therapy in keratinocyte skin cancer, thereby enhancing treatment outcomes?</p> Materials and methods <p>Description of the process using a&#xa0;patient pathway and case studies, with discussion of existing literature and future perspectives.</p> Results and discussion <p>Modern noninvasive imaging techniques such as line-field confocal optical coherence tomography (LC-OCT) offer promising approaches in the surgical treatment of keratinocyte skin cancer, enabling high-resolution real-time tumor diagnostics. Early studies show that LC-OCT can be used both for early diagnosis without biopsy and for preoperative margin delineation of basal cell carcinomas. These techniques allow for efficiency-enhancing concepts in modern tumor therapy. However, clinical data on the practicability of these methods are currently lacking, highlighting the urgent need for validated studies for critical evaluation.</p> Conclusion <p>Noninvasive imaging can increase the efficiency of diagnosis and treatment of keratinocyte tumors through early and rapid diagnosis as well as artificial intelligence-assisted surgical planning.</p>