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Background <p>Malnutrition poses a&#xa0;significant risk for patients with non-small cell lung cancer (NSCLC). A&#xa0;reduced nutritional status is associated with functional decline and perioperative complications, thereby impairing treatment success and prognosis.</p> Methods <p>A&#xa0;retrospective single-center cohort study including 197 NSCLC patients who underwent curative surgery between 2015 and 2024 was conducted. The aim was to examine the relationship between preoperative nutritional status, postoperative outcome and long-term prognosis in NSCLC patients.</p> Results <p>Based on age-adjusted body mass index (BMI) 28.4% of patients were underweight, 35.5% normal weight and 36.1% overweight. Approximately one third of the patients had a nutritional risk scoring (NRS) ≥ 3 and 65% a&#xa0;Grazer malnutrition screening (GMS) ≥ 3, each indicating a&#xa0;risk of malnutrition. A&#xa0;C-reactive protein-albumin ratio (CAR) ≥ 0.144 was observed in 44.2% of patients. Severe postoperative complications (Clavien-Dindo classification, CDC ≥ °III) were associated with NRS ≥ 3, GMS ≥ 3 and CAR ≥ 0.144. Patients with elevated NRS and GMS scores showed a&#xa0;higher risk of recurrence and mortality. An increase in CAR by 1 was associated with a&#xa0;41% higher mortality risk.</p> Conclusion <p>The preoperative nutritional status influenced postoperative outcomes after curative surgery. Given the predictive relevance of individual parameters, nutritional screening should be performed multiparametrically. Further studies are needed to translate these findings into clinical practice and prehabilitation-based nutritional strategies.</p>

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Mangelernährung bei Patienten mit Lungenkrebs

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • T. Rabenhold,
  • M. Krüger,
  • W. Schütte,
  • M. Möller,
  • N. M. Dörr-Jerat

摘要

Background

Malnutrition poses a significant risk for patients with non-small cell lung cancer (NSCLC). A reduced nutritional status is associated with functional decline and perioperative complications, thereby impairing treatment success and prognosis.

Methods

A retrospective single-center cohort study including 197 NSCLC patients who underwent curative surgery between 2015 and 2024 was conducted. The aim was to examine the relationship between preoperative nutritional status, postoperative outcome and long-term prognosis in NSCLC patients.

Results

Based on age-adjusted body mass index (BMI) 28.4% of patients were underweight, 35.5% normal weight and 36.1% overweight. Approximately one third of the patients had a nutritional risk scoring (NRS) ≥ 3 and 65% a Grazer malnutrition screening (GMS) ≥ 3, each indicating a risk of malnutrition. A C-reactive protein-albumin ratio (CAR) ≥ 0.144 was observed in 44.2% of patients. Severe postoperative complications (Clavien-Dindo classification, CDC ≥ °III) were associated with NRS ≥ 3, GMS ≥ 3 and CAR ≥ 0.144. Patients with elevated NRS and GMS scores showed a higher risk of recurrence and mortality. An increase in CAR by 1 was associated with a 41% higher mortality risk.

Conclusion

The preoperative nutritional status influenced postoperative outcomes after curative surgery. Given the predictive relevance of individual parameters, nutritional screening should be performed multiparametrically. Further studies are needed to translate these findings into clinical practice and prehabilitation-based nutritional strategies.