Geschlechtsspezifische Unterschiede in der Entwicklung kolorektaler Karzinome bei Lynch-Syndrom-Betroffenen – ein systematisches Review

Lynch syndrome (LS) is the most frequent hereditary tumor syndrome and is associated with an increased risk of colorectal cancer (CRC). While gene-specific and age-specific differences are considered in patient surveillance, gender-specific risks in the development of CRC have been reported in many studies but are not consistently documented.

This systematic review aims to investigate gender-specific differences in CRC development among LS patients.

A systematic literature search following PRISMA 2020 guidelines was conducted in the PubMed, Ovid, The Cochrane Library and Web of Science databases. A total of 688 studies were screened, and 41 met the inclusion criteria.

Men have a higher risk of CRC and develop CRC earlier compared to women.

These findings indicate gender-specific differences in the risk of CRC among LS patients, although they do not currently justify separate surveillance strategies.