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<p>Gene doping refers to the use of gene therapeutic substances or technologies for the purpose of illicit sport performance enhancement. A&#xa0;wide variety of doping analytical detection methods are currently under development, ranging from PCR&#xa0;(Polymerase Chain Reaction) to high-resolution mass spectrometry to clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (CRISPR/Cas)-based detection methods. Due to the diverse approaches in gene therapy clinical research, it can be assumed that a&#xa0;wide variety of methods will also be needed to detect cases of gene doping. The increasing availability of unapproved gene doping-related products on the open consumer market underscores the urgent need to establish new detection methods for routine doping control analysis.</p>

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Gen-Doping: aktuelle Nachweisverfahren und analytische Herausforderungen

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月3日

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  • Mario Thevis,
  • Andreas Thomas,
  • Nana Naumann

摘要

Gene doping refers to the use of gene therapeutic substances or technologies for the purpose of illicit sport performance enhancement. A wide variety of doping analytical detection methods are currently under development, ranging from PCR (Polymerase Chain Reaction) to high-resolution mass spectrometry to clustered regularly interspaced short palindromic repeat (CRISPR) and CRISPR-associated (CRISPR/Cas)-based detection methods. Due to the diverse approaches in gene therapy clinical research, it can be assumed that a wide variety of methods will also be needed to detect cases of gene doping. The increasing availability of unapproved gene doping-related products on the open consumer market underscores the urgent need to establish new detection methods for routine doping control analysis.