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Background <p>Preparations containing plant-derived components, such as those found in herbal medicinal products, medical devices, dietary supplements, and cosmetics, are readily accessible and may lead to adverse effects or poisoning if used incorrectly. Poison information centers (PICs) respond to exposure-related inquiries. The aim of this study was to analyze exposure inquiries concerning preparations with plant-derived components at the Joint Poison Information Center in Erfurt (GGIZ) in order to identify preventive approaches.</p> Methods <p>A&#xa0;statistical analysis of exposure inquiries received by the GGIZ from 2013 to 2022 was conducted. Data from nine federal states were included. Only inquiries related to single preparations that had been reported at least 10 times were considered. Symptom severity was assessed using the poisoning severity score (PSS), and poisoning risk was calculated using a&#xa0;modified Litovitz risk factor.</p> Results <p>A&#xa0;total of 36&#xa0;preparations with 2512 exposures (mean 251.2/year; trend τ = 0.8667, <i>p</i> = 0.0007) were identified. Of those affected, 60.2% (1511) were toddlers. Most exposures (98.5%, 2474) occurred in the home environment. In 64.5% (1620) of cases, exposures were unintentional. Oral exposure accounted for 93.4% (2345) of cases. Of the exposures with known outcomes, 75.3% (1780/2365) remained asymptomatic, 23.5% (556/2365) resulted in minor/mild symptoms, 1% (24)&#xa0;in moderate symptoms, and 0.2% (5)&#xa0;in severe symptoms. Severe intoxications were associated with Colchysat® Bürger and Klosterfrau® Melissengeist concentrate.</p> Discussion <p>Toddlers represent a&#xa0;relevant risk group in the use of preparations containing plant-derived components. Preparations containing colchicine or ethanol may lead to fatal intoxications, particularly in cases of intentional exposure. It is recommended to store oral and topical preparations separately and out of reach of unauthorized persons, and to provide comprehensive education.</p>

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Expositionsanfragen zu Zubereitungen mit pflanzlichen Bestandteilen in Deutschland: Analyse von Anfragen (2013–2022) am Gemeinsamen Giftinformationszentrum Erfurt

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年4月29日

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  • Sebastian Wendt,
  • Daniel Linden,
  • Dagmar Prasa,
  • Heike Franke

摘要

Background

Preparations containing plant-derived components, such as those found in herbal medicinal products, medical devices, dietary supplements, and cosmetics, are readily accessible and may lead to adverse effects or poisoning if used incorrectly. Poison information centers (PICs) respond to exposure-related inquiries. The aim of this study was to analyze exposure inquiries concerning preparations with plant-derived components at the Joint Poison Information Center in Erfurt (GGIZ) in order to identify preventive approaches.

Methods

A statistical analysis of exposure inquiries received by the GGIZ from 2013 to 2022 was conducted. Data from nine federal states were included. Only inquiries related to single preparations that had been reported at least 10 times were considered. Symptom severity was assessed using the poisoning severity score (PSS), and poisoning risk was calculated using a modified Litovitz risk factor.

Results

A total of 36 preparations with 2512 exposures (mean 251.2/year; trend τ = 0.8667, p = 0.0007) were identified. Of those affected, 60.2% (1511) were toddlers. Most exposures (98.5%, 2474) occurred in the home environment. In 64.5% (1620) of cases, exposures were unintentional. Oral exposure accounted for 93.4% (2345) of cases. Of the exposures with known outcomes, 75.3% (1780/2365) remained asymptomatic, 23.5% (556/2365) resulted in minor/mild symptoms, 1% (24) in moderate symptoms, and 0.2% (5) in severe symptoms. Severe intoxications were associated with Colchysat® Bürger and Klosterfrau® Melissengeist concentrate.

Discussion

Toddlers represent a relevant risk group in the use of preparations containing plant-derived components. Preparations containing colchicine or ethanol may lead to fatal intoxications, particularly in cases of intentional exposure. It is recommended to store oral and topical preparations separately and out of reach of unauthorized persons, and to provide comprehensive education.