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Background <p>This study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia.</p> Materials and methods <p>In our study, a total of 21 male New Zealand rabbits were used, and the animals were divided into three groups for the study. Blood samples were taken for adrenomedullin and HIF1-alpha levels at 0, 1, 3, and 6&#xa0;h from the control, sham, ischemia groups.</p> Results <p>HIF levels of the ischemia group at the 3rd and 6th hours were statistically significantly higher than those in the sham (<i>p</i> = 0.002, <i>p</i> &lt; 0.001, respectively) and control groups (<i>p</i> = 0.002, <i>p</i> &lt; 0.001, respectively). Adrenomedullin levels of the ischemia group at the 1st, 3rd, and 6th hours were statistically significantly higher than those in the sham (<i>p</i> = 0.004, <i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001, respectively) and control groups (<i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001, <i>p</i> &lt; 0.001 respectively).</p> Conclusion <p>In this experimental model of acute mesenteric ischemia, hypoxia-inducible factor-1 alpha and adrenomedullin levels were significantly higher in the ischemia group compared with the control and sham groups. Adrenomedullin demonstrated an earlier increase, while hypoxia-inducible factor-1 alpha increased significantly at later time points. These biomarkers may provide supportive diagnostic value when interpreted alongside clinical and imaging findings; however, further clinical studies are required to confirm their role in the early diagnosis of acute mesenteric ischemia.</p>

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Diagnostic value of hypoxia-inducible factor 1 alpha and adrenomedullin in acute mesenteric ischemia

  • 期刊论文

  • 发表日期：

    2026年4月27日

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  • Enes Bayindir,
  • Kadir Küçükceran,
  • Muhammet Raşit Özer,
  • Mustafa Kürşat Ayranci,
  • İbrahim Kilinç,
  • Naile Kökbudak,
  • Gamze Kaygisiz Bayindir

摘要

Background

This study aims to evaluate the diagnostic significance of adrenomedullin and hypoxia-inducible factor 1 alpha (HIF1-alpha) levels in an animal model of acute mesenteric ischemia.

Materials and methods

In our study, a total of 21 male New Zealand rabbits were used, and the animals were divided into three groups for the study. Blood samples were taken for adrenomedullin and HIF1-alpha levels at 0, 1, 3, and 6 h from the control, sham, ischemia groups.

Results

HIF levels of the ischemia group at the 3rd and 6th hours were statistically significantly higher than those in the sham (p = 0.002, p < 0.001, respectively) and control groups (p = 0.002, p < 0.001, respectively). Adrenomedullin levels of the ischemia group at the 1st, 3rd, and 6th hours were statistically significantly higher than those in the sham (p = 0.004, p < 0.001, p < 0.001, respectively) and control groups (p < 0.001, p < 0.001, p < 0.001 respectively).

Conclusion

In this experimental model of acute mesenteric ischemia, hypoxia-inducible factor-1 alpha and adrenomedullin levels were significantly higher in the ischemia group compared with the control and sham groups. Adrenomedullin demonstrated an earlier increase, while hypoxia-inducible factor-1 alpha increased significantly at later time points. These biomarkers may provide supportive diagnostic value when interpreted alongside clinical and imaging findings; however, further clinical studies are required to confirm their role in the early diagnosis of acute mesenteric ischemia.