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Background <p>Chest trauma accounts for nearly one-third of severe trauma cases and is associated with cardiac complications that increase morbidity and mortality. The utility of repeated high-sensitivity troponin I (hsTnI) testing in this context remains uncertain, particularly with the advent of ultra-sensitive assays.</p> Methods <p>We conducted a retrospective cohort study of 1,749 intensive care patients with chest trauma who underwent hsTnI testing. Cardiac complications during intensive care hospitalisation and 30-day mortality were recorded. Predictive performance of initial hsTnI was assessed using receiver operating characteristic curve (ROC) analysis, and associations between hsTnI values (initial and dynamic changes) and complications were tested in a multivariate logistic regression model adjusted for age and severity (SAPS II Score).</p> Results <p>Cardiac complications occurred in 64 patients (3.7%), most frequently arrhythmias (1.6%). Initial hsTnI showed moderate predictive value (AUROC 0.74), with a threshold of 12.9 ng/L providing 73% sensitivity and 71% specificity. Patients with complications were older, had higher SAPS II scores, prolonged ICU stays, greater need for organ support, and increased 30-day mortality. In a multivariate model, neither initial hsTnI nor its variation independently predicted complications, whereas age and SAPS II remained significant predictors.</p> Conclusion <p>Cardiac complications after thoracic trauma are infrequent but strongly associated with adverse outcomes. Initial hsTnI offers only moderate prognostic performance, and a second testing does not improve risk stratification. Age and severity scores are stronger predictors of complications in this setting.</p>

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Effectiveness of high-sensitivity troponin I to predict cardiovascular events in chest trauma patients

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年1月29日

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  • Baptiste Milley,
  • Xavier-Jean Taverna,
  • Stanislas Abrard,
  • Sophie Debord-Peguet,
  • François-Xavier Jean,
  • Régine Cartier,
  • Anne-Claire Lukaszewicz,
  • Pauline Pérèz

摘要

Background

Chest trauma accounts for nearly one-third of severe trauma cases and is associated with cardiac complications that increase morbidity and mortality. The utility of repeated high-sensitivity troponin I (hsTnI) testing in this context remains uncertain, particularly with the advent of ultra-sensitive assays.

Methods

We conducted a retrospective cohort study of 1,749 intensive care patients with chest trauma who underwent hsTnI testing. Cardiac complications during intensive care hospitalisation and 30-day mortality were recorded. Predictive performance of initial hsTnI was assessed using receiver operating characteristic curve (ROC) analysis, and associations between hsTnI values (initial and dynamic changes) and complications were tested in a multivariate logistic regression model adjusted for age and severity (SAPS II Score).

Results

Cardiac complications occurred in 64 patients (3.7%), most frequently arrhythmias (1.6%). Initial hsTnI showed moderate predictive value (AUROC 0.74), with a threshold of 12.9 ng/L providing 73% sensitivity and 71% specificity. Patients with complications were older, had higher SAPS II scores, prolonged ICU stays, greater need for organ support, and increased 30-day mortality. In a multivariate model, neither initial hsTnI nor its variation independently predicted complications, whereas age and SAPS II remained significant predictors.

Conclusion

Cardiac complications after thoracic trauma are infrequent but strongly associated with adverse outcomes. Initial hsTnI offers only moderate prognostic performance, and a second testing does not improve risk stratification. Age and severity scores are stronger predictors of complications in this setting.