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Objective <p>Severe hemorrhage is one of the predominant causes of death among trauma patients. Conventional techniques often prove insufficient&#xa0;for hemostasis in junctional injuries. Therefore, this study independently&#xa0;developed&#xa0;a disposable sterile hemostatic clamp.&#xa0;Swine groin&#xa0;models were utilized to evaluate its&#xa0;efficacy.</p> Methods <p>10 healthy Bama Xiang boars aged 6–7&#xa0;months were divided to two groups. After femoral artery incision, the control group were treated with bandages and the experimental group were treated with hemostatic clamps. The survival rate, survival time, hemostatic operation time, and blood loss were recorded. Local joints were repeatedly flexed to assess the stability of the hemostatic clamp. Physiological parameters were monitored and recorded. Ultrasound was used to observe blood flow perfusion. Local skin was examined&#xa0;and femoral arteries were taken for pathological staining.</p> Results <p>In experimental group and control group, all 5 (100%) and 3 (60%) animals survived, respectively. The survival time of experimental group was all &gt; 180&#xa0;min, the median survival time and interquartile range of control group were 180&#xa0;min and 68&#xa0;min. The hemostatic procedures time were 22.50 ± 2.89&#xa0;min and 57.25 ± 13.60&#xa0;min, and blood loss were 190 ± 100&#xa0;g and 549 ± 195&#xa0;g, respectively.&#xa0;Ultrasound showed the clamp effectively reduced distal arterial blood flow. It was well-fixed after joint movement, while bandages were loose. No skin damage was observed. Femoral arteries in experimental group showed intravascular thrombosis, while no thrombosis&#xa0;was oberserved in control.</p> Conclusion <p>Compared to traditional bandaging, the hemostatic clamp may help to reduce blood loss and stabilize vital signs, demonstrating its potential in controlling severe pre-hospital hemorrhage.</p>

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Application and observation of hemostatic effect of independently developed hemostatic equipment in a lethal swine exsanguination model

  • 期刊论文

  • 发表日期：

    2026年1月13日

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  • Huijuan Fu,
  • Ye Tang,
  • Mingjian Bei,
  • Yanhua Wang,
  • Yangyang Wu,
  • Yehui Lu,
  • Liu Zhang,
  • Dianying Zhang

摘要

Objective

Severe hemorrhage is one of the predominant causes of death among trauma patients. Conventional techniques often prove insufficient for hemostasis in junctional injuries. Therefore, this study independently developed a disposable sterile hemostatic clamp. Swine groin models were utilized to evaluate its efficacy.

Methods

10 healthy Bama Xiang boars aged 6–7 months were divided to two groups. After femoral artery incision, the control group were treated with bandages and the experimental group were treated with hemostatic clamps. The survival rate, survival time, hemostatic operation time, and blood loss were recorded. Local joints were repeatedly flexed to assess the stability of the hemostatic clamp. Physiological parameters were monitored and recorded. Ultrasound was used to observe blood flow perfusion. Local skin was examined and femoral arteries were taken for pathological staining.

Results

In experimental group and control group, all 5 (100%) and 3 (60%) animals survived, respectively. The survival time of experimental group was all > 180 min, the median survival time and interquartile range of control group were 180 min and 68 min. The hemostatic procedures time were 22.50 ± 2.89 min and 57.25 ± 13.60 min, and blood loss were 190 ± 100 g and 549 ± 195 g, respectively. Ultrasound showed the clamp effectively reduced distal arterial blood flow. It was well-fixed after joint movement, while bandages were loose. No skin damage was observed. Femoral arteries in experimental group showed intravascular thrombosis, while no thrombosis was oberserved in control.

Conclusion

Compared to traditional bandaging, the hemostatic clamp may help to reduce blood loss and stabilize vital signs, demonstrating its potential in controlling severe pre-hospital hemorrhage.