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Purpose <p>The cerebral blood flow (CBF) measured by multi-delay ASL (4D-ASL) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Dynamic changes in signal intensity (SI) and arterial transit time (ATT) obtained from 4D-ASL may also be key factors in differentiating adult-type diffuse glioma. Furthermore, the longitudinal relaxation time (T1) of brain tumor may influence on CBF and ATT when using ASL techniques. Our purpose was to determine if time-intensity profiles from 4D-ASL using a&#xa0;variable-TR scheme and T1-corrected ATT (ATT<sub>T1corr</sub>) could distinguish among adult-type diffuse gliomas.</p> Materials and Methods <p>The 4D-ASL with a&#xa0;variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A&#xa0;total of 14&#xa0;LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a&#xa0;variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATT<sub>T1corr</sub> were compared among adult-type diffuse gliomas.</p> Results <p>Thirty patients were included in the study. ATT and the SI peak time in diffuse glioma with <i>IDH-wildtype</i> (<i>IDHw</i>) were significantly shorter than astrocytoma, <i>IDH-mutant</i> (<i>p</i> &lt; 0.01, each). Moreover, ATT<sub>T1corr</sub> in astrocytoma, <i>IDH-mutant</i> was longer than the other types of diffuse glioma (<i>p</i> &lt; 0.0001).</p> Conclusion <p>The 4D-ASL with a&#xa0;variable-TR scheme includes ATT<sub>T1corr</sub> and the SI peak time could potentially improve the differential diagnosis of adult-type diffuse gliomas.</p>

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Time-intensity Profiles and T1-corrected Arterial Transit Time from Multi-delay Pseudo-continuous ASL with a Variable-TR Scheme for the Characterization of Adult-type Diffuse Glioma

  • 期刊论文

  • 发表日期：

    2026年1月20日

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  • Koji Yamashita,
  • Makoto Obara,
  • Kazufumi Kikuchi,
  • Ryoji Mikayama,
  • Daichi Momosaka,
  • Masaoki Kusunoki,
  • Daisuke Kuga,
  • Ryusuke Hatae,
  • Yutaka Fujioka,
  • Ryosuke Otsuji,
  • Tatsuhiro Wada,
  • Chiaki Tokunaga,
  • Marc Van Cauteren,
  • Osamu Togao,
  • Koji Yoshimoto,
  • Kousei Ishigami

摘要

Purpose

The cerebral blood flow (CBF) measured by multi-delay ASL (4D-ASL) offers superior diagnostic performance compared to single-delay ASL-CBF for glioma grading. Dynamic changes in signal intensity (SI) and arterial transit time (ATT) obtained from 4D-ASL may also be key factors in differentiating adult-type diffuse glioma. Furthermore, the longitudinal relaxation time (T1) of brain tumor may influence on CBF and ATT when using ASL techniques. Our purpose was to determine if time-intensity profiles from 4D-ASL using a variable-TR scheme and T1-corrected ATT (ATTT1corr) could distinguish among adult-type diffuse gliomas.

Materials and Methods

The 4D-ASL with a variable-TR scheme data were collected by changing the labeling duration (LD) and post-labeling delay (PLD). Data acquisition at each phase consisted of pre-saturation and control or labeling modules followed by data acquisition. A total of 14 LD and PLD combinations were used. In addition, T1 measurement was conducted using pseudo-continuous ASL with a variable-TR scheme, without label and background suppression pulses. The SI peak time was obtained based on the time-intensity curve. The SI peak time, ATT, and ATTT1corr were compared among adult-type diffuse gliomas.

Results

Thirty patients were included in the study. ATT and the SI peak time in diffuse glioma with IDH-wildtype (IDHw) were significantly shorter than astrocytoma, IDH-mutant (p < 0.01, each). Moreover, ATTT1corr in astrocytoma, IDH-mutant was longer than the other types of diffuse glioma (p < 0.0001).

Conclusion

The 4D-ASL with a variable-TR scheme includes ATTT1corr and the SI peak time could potentially improve the differential diagnosis of adult-type diffuse gliomas.