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Purpose <p>Prognosis and therapeutic approaches to meningiomas are determined by their proliferative activity and tumor grade. The early identification of aggressive phenotypes is hence essential to improving outcomes. Here, we investigated the potential of shape-based radiomics features and surface regularity (SR) as non-invasive biomarkers of atypical (grade&#xa0;2) and anaplastic (grade&#xa0;3) meningiomas.</p> Methods <p>In this retrospective single-center study, we assessed individuals with treatment-naive meningiomas in a&#xa0;comprehensive analysis of MR imaging with histopathological grading and quantification of mitotic activity. Radiomics (sphericity, elongation, flatness) and SR measures were calculated on segmented contrast-enhancing tumor components and tested for association with WHO grade (<i>n</i> = 62 grade&#xa0;1, <i>n</i> = 71 grade&#xa0;2, and <i>n</i> = 19 grade&#xa0;3) and proliferation.</p> Results <p>All tumor grades were significantly different in characteristics of sphericity and SR with decreasing values at higher tumor grades as an expression of a&#xa0;more irregular shape. Additionally, radiomics features of tumor elongation and flatness discriminated grade&#xa0;3&#xa0;cases from grade&#xa0;1 (<i>p</i> = 0.0008 and <i>p</i> = 0.0003) and grade&#xa0;2 meningiomas (<i>p</i> = 0.0008 and <i>p</i> = 0.0013). Mitotic activity exhibited a&#xa0;significant negative correlation with the four imaging markers assessed (<i>p</i> &lt; 0.003).</p> Conclusion <p>Shape-based radiomics features of sphericity and SR can serve as preoperative grading biomarkers of meningiomas in routine contrast-enhanced T1w MRI.</p>

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Non-invasive Prediction of Meningioma Tumor Grade by Quantification of Shape-based Radiomics Features and Surface Regularity

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年9月17日

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  • Martin Diebold,
  • Lucas Becker,
  • Theo Demerath,
  • Marco Reisert,
  • Daniel Erny,
  • Andreas Braun,
  • Till-Karsten Hauser,
  • Jürgen Grauvogel,
  • Marc Hohenhaus,
  • Horst Urbach,
  • Alexander Rau,
  • Urs Würtemberger

摘要

Purpose

Prognosis and therapeutic approaches to meningiomas are determined by their proliferative activity and tumor grade. The early identification of aggressive phenotypes is hence essential to improving outcomes. Here, we investigated the potential of shape-based radiomics features and surface regularity (SR) as non-invasive biomarkers of atypical (grade 2) and anaplastic (grade 3) meningiomas.

Methods

In this retrospective single-center study, we assessed individuals with treatment-naive meningiomas in a comprehensive analysis of MR imaging with histopathological grading and quantification of mitotic activity. Radiomics (sphericity, elongation, flatness) and SR measures were calculated on segmented contrast-enhancing tumor components and tested for association with WHO grade (n = 62 grade 1, n = 71 grade 2, and n = 19 grade 3) and proliferation.

Results

All tumor grades were significantly different in characteristics of sphericity and SR with decreasing values at higher tumor grades as an expression of a more irregular shape. Additionally, radiomics features of tumor elongation and flatness discriminated grade 3 cases from grade 1 (p = 0.0008 and p = 0.0003) and grade 2 meningiomas (p = 0.0008 and p = 0.0013). Mitotic activity exhibited a significant negative correlation with the four imaging markers assessed (p < 0.003).

Conclusion

Shape-based radiomics features of sphericity and SR can serve as preoperative grading biomarkers of meningiomas in routine contrast-enhanced T1w MRI.