Clinical Outcomes On Tubridge Flow Diverter in Treatmenting Intracranial Aneurysms: a Retrospective Multicenter Registry Study

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发表日期：

2024年2月15日

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Qiang Li,
Deyuan Zhu,
Nan Lv,
Pengfei Yang,
Yu Zhou,
Rui Zhao,
Wenjin Yang,
Ming Lv,
Tianxiao Li,
Wenyuan Zhao,
Tiewei Qi,
Weixi Jiang,
Chuanzhi Duan,
Guangyu Zhao,
Guoli Duan,
Yina Wu,
Qian Zheng,
Zifu Li,
Qiao Zuo,
Dongwei Dai,
Yibin Fang,
Qinghai Huang,
Bo Hong,
Yi Xu,
Yuxiang Gu,
Sheng Guan,
Jianmin Liu

摘要

Purpose

In China, the application of nitinol Tubridge flow diverter (TFD) has become popular for treating intracranial aneurysms (IAs). In this study, we investigated the safety outcomes of the application of TFD for treating IAs in real-world scenarios.

Methods

We retrospectively analyzed aneurysms treated with TFD in 235 centers throughout China between April 2018 and April 2020. The primary endpoint was the event-free survival rate at 12 months, defined as the occurrence of morbidity (spontaneous rupture, intraparenchymal hemorrhage (IPH), ischemic stroke, and permanent cranial neuropathy) or death. Univariate and multivariate analyses were performed to assess the risk factors. A good outcome was defined as a modified Rankin Score (mRS) of 0–2.

Results

We included 1281 unruptured aneurysms treated with TFD. The overall neurological morbidity and death rates after 12 months were 5.4 and 2.8%, respectively. Ischemic strokes were the most common complication (4.2%, P < 0.001). Cranial neuropathy, IPH, and spontaneous rupture occurred in 0.3%, 0.3%, and 0.5% of aneurysms, respectively. Univariate and multivariate analyses indicated that the male gender, older age, larger aneurysm diameter, and aneurysm located on BA were the independent risk factors for neurologic events. Aneurysm located on BA was the independent risk factor for ischemic strokes. Most patients (1222) had access to the mRS, and 93.2% of them achieved good outcomes.

Conclusion

Treatment of IAs with TFD was associated with low morbidity and mortality, most of which were ischemic events. Large posterior aneurysms might be associated with a higher complication rate.

Trial Registration

Retrospectively registered.