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Background <p>Acne inversa, also known as hidradenitis suppurativa, is a&#xa0;chronic relapsing inflammatory disease of the terminal hair follicles characterized by painful nodules, abscesses, secretions, tunnel formation and scarring. Beyond the considerable somatic disease burden, patients frequently experience pronounced psychosocial distress and relevant socioeconomic consequences.</p> Research question <p>The aim of this review article is to provide coloproctologically active, primarily surgically oriented physicians with a&#xa0;structured guideline-based overview of the pharmacotherapy of acne inversa and to illustrate its importance for early disease control and for improvement of the operative situation.</p> Material and methods <p>This narrative review is based on the Association of the Scientific Medical Societies in Germany (AWMF) S2k guidelines for the treatment of acne inversa (registry number 013-012). In addition, current prescription information of approved medications and selected scientific publications were taken into account.</p> Results <p>In cases of mild disease, topical antiseptic or antibiotic measures, such as clindamycin 1% can be used. In active or recurrent disease activity, systemic antibiotic drugs represent a&#xa0;key treatment component when used for a&#xa0;limited period of time. In moderate to severe disease, biologics are indicated according to the current guidelines. Approved agents include adalimumab from the age of 12&#xa0;years as well as secukinumab and bimekizumab for adult patients. During inflammatory flares, combination therapy with biologics and antibiotics can be considered.</p> Conclusion <p>The importance of pharmacotherapy is steadily increasing, as early and effective control of inflammation can reduce the progression to chronic tunnels and fistulous structures as well as prevent or delay surgical interventions or improve their extent and predictability. Due to the high prevalence of psychological comorbidities, including depression and suicidal ideation, particular clinical attention is required.</p>

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Acne inversa – medikamentöse Therapie

  • 期刊论文

  • 发表日期：

    2026年5月11日

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  • Dariusch Mortazawi

摘要

Background

Acne inversa, also known as hidradenitis suppurativa, is a chronic relapsing inflammatory disease of the terminal hair follicles characterized by painful nodules, abscesses, secretions, tunnel formation and scarring. Beyond the considerable somatic disease burden, patients frequently experience pronounced psychosocial distress and relevant socioeconomic consequences.

Research question

The aim of this review article is to provide coloproctologically active, primarily surgically oriented physicians with a structured guideline-based overview of the pharmacotherapy of acne inversa and to illustrate its importance for early disease control and for improvement of the operative situation.

Material and methods

This narrative review is based on the Association of the Scientific Medical Societies in Germany (AWMF) S2k guidelines for the treatment of acne inversa (registry number 013-012). In addition, current prescription information of approved medications and selected scientific publications were taken into account.

Results

In cases of mild disease, topical antiseptic or antibiotic measures, such as clindamycin 1% can be used. In active or recurrent disease activity, systemic antibiotic drugs represent a key treatment component when used for a limited period of time. In moderate to severe disease, biologics are indicated according to the current guidelines. Approved agents include adalimumab from the age of 12 years as well as secukinumab and bimekizumab for adult patients. During inflammatory flares, combination therapy with biologics and antibiotics can be considered.

Conclusion

The importance of pharmacotherapy is steadily increasing, as early and effective control of inflammation can reduce the progression to chronic tunnels and fistulous structures as well as prevent or delay surgical interventions or improve their extent and predictability. Due to the high prevalence of psychological comorbidities, including depression and suicidal ideation, particular clinical attention is required.