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<p>A series of new bis-1,3,4-oxadiazoles was synthesized by reacting the corresponding dicarboxylic acid bishydrazides with dialkyl chloroethynyl phosphonate. The resulting compounds were tested against a range of test cultures: <i>Staphylococcus aureus</i> ATCC6538; <i>Pseudomonas aeruginosa</i> 0387; and <i>Candida utilis</i> LIA-01. All synthesized compounds exhibited antistaphylococcal activity and fungistatic action. The cytotoxicity and antiviral activity of the obtained compounds against the influenza A (H1N1) virus was studied in vitro. Two of seven compounds under investigation (28%) have demonstrated high anti-viral activity against influenza virus A/Puerto Rico/8/34 (H1N1) with selectivity indices of 15 and 24.</p><p></p>

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Synthesis of new phosphonylated bis-1,3,4-oxadiazoles and study of their antimicrobial and antiviral activity

  • 期刊论文

  • 发表日期：

    2025年12月16日

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  • Elizaveta A. Gerasimova,
  • Dmitry M. Egorov,
  • Aleksandr S. Krylov,
  • Ekaterina N. Chernova,
  • Dar’ya V. Spiridonova,
  • Irina L. Kuzikova,
  • Tatyana B. Zaytseva,
  • Zoya A. Zhakovskaya,
  • Alexandrina S. Volobueva,
  • Maria A. Niukalova,
  • Vladimir V. Zarubaev

摘要

A series of new bis-1,3,4-oxadiazoles was synthesized by reacting the corresponding dicarboxylic acid bishydrazides with dialkyl chloroethynyl phosphonate. The resulting compounds were tested against a range of test cultures: Staphylococcus aureus ATCC6538; Pseudomonas aeruginosa 0387; and Candida utilis LIA-01. All synthesized compounds exhibited antistaphylococcal activity and fungistatic action. The cytotoxicity and antiviral activity of the obtained compounds against the influenza A (H1N1) virus was studied in vitro. Two of seven compounds under investigation (28%) have demonstrated high anti-viral activity against influenza virus A/Puerto Rico/8/34 (H1N1) with selectivity indices of 15 and 24.