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<p>Cancer is a wound that never heals and is the second leading cause of death worldwide. Ginsenoside Rh2 (G-Rh2) is the main active substance extracted from Panax ginseng c.a. Meyer, has anticancer activity. G-Rh2 can inhibit tumor cell proliferation, migration, invasion, and neovascularization, regulate immune function, and induce apoptosis and cycle blockade in vitro and in vivo. In addition, G-Rh2 can be used as an adjuvant to chemotherapeutic drugs to enhance their anticancer effects and reverse adverse effects. In this study, the anti-tumor mechanism of G-Rh2 was organized and reviewed by reviewing relevant reports in recent years to provide guidance for the application of G-Rh2 in clinical tumor therapy.</p><p></p>

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Advances in preclinical studies of ginsenoside Rh2 in antitumor therapy

  • 期刊论文

  • 发表日期：

    2025年9月5日

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  • Zheng Xu,
  • Guanghuan Shen,
  • Zhihua Xing,
  • Jianghan Luo,
  • Yu Zhu,
  • Xuan Liu,
  • ShiHao Li,
  • Hao Wang,
  • Linlin Cui

摘要

Cancer is a wound that never heals and is the second leading cause of death worldwide. Ginsenoside Rh2 (G-Rh2) is the main active substance extracted from Panax ginseng c.a. Meyer, has anticancer activity. G-Rh2 can inhibit tumor cell proliferation, migration, invasion, and neovascularization, regulate immune function, and induce apoptosis and cycle blockade in vitro and in vivo. In addition, G-Rh2 can be used as an adjuvant to chemotherapeutic drugs to enhance their anticancer effects and reverse adverse effects. In this study, the anti-tumor mechanism of G-Rh2 was organized and reviewed by reviewing relevant reports in recent years to provide guidance for the application of G-Rh2 in clinical tumor therapy.