<p>The therapeutic efficacy of cisplatin, a commonly used chemotherapeutic drug, is limited by its substantial nephrotoxicity. Despite its clinical significance, cisplatin-induced kidney damage is still a significant problem that calls for the creation of preventative measures for renal function. The potential of natural products as nephroprotective agents against cisplatin-induced nephrotoxicity has been brought to light by recent studies. This review offers a thorough summary of the most recent research examining the protective properties of several natural substances, such as flavonoids, alkaloids, terpenoids, polyphenols, and other bioactive chemicals produced by plants. Nephroprotective mechanisms include anti-inflammatory, anti-apoptotic, anti-fibrotic, and antioxidant properties that work together to reduce oxidative stress, inflammation, and cellular damage brought on by cisplatin. This review also addresses the difficulties in putting these results into clinical practice, such as concerns about safety, dose, and bioavailability. All things considered, the natural items under evaluation exhibit encouraging nephroprotective potential, indicating that they could be useful supplements or substitute therapies for the management of cisplatin-induced nephrotoxicity. This review explains the importance of natural substances against the nephrotoxicity induced by cisplatin in rodents. To confirm their safety and therapeutic effectiveness in humans, more investigation and clinical testing are required.</p><p></p>