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<p>Paeoniflorin is one of the active components of the root of <i>peony</i>, which has powerful and diverse pharmacological activities. However, low membrane permeability and gastrointestinal effects severely limit its absorption and bioavailability. In this paper, 190 paeoniflorin derivatives, including natural derivatives and synthetic derivatives, were collected. The pharmacological effects of the more active derivatives were summarized. In addition, the structure-activity relationship of paeoniflorin was appropriately summarized. This review aims to provide valuable assistance for further research and clinical application of paeoniflorin.</p>

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Summary of paeoniflorin derivatives and their biological activities

  • 期刊论文

  • 发表日期：

    2025年6月5日

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  • Qian Xiao,
  • Hua Han,
  • Peiliang Dong

摘要

Paeoniflorin is one of the active components of the root of peony, which has powerful and diverse pharmacological activities. However, low membrane permeability and gastrointestinal effects severely limit its absorption and bioavailability. In this paper, 190 paeoniflorin derivatives, including natural derivatives and synthetic derivatives, were collected. The pharmacological effects of the more active derivatives were summarized. In addition, the structure-activity relationship of paeoniflorin was appropriately summarized. This review aims to provide valuable assistance for further research and clinical application of paeoniflorin.