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<p>Diabetes mellitus is a chronic disorder characterized by hyperglycemia and is caused by metabolic dysregulation. According to a report from the World Health Organization (WHO), in 2014, more than 422 million people in the world were diagnosed with diabetes. In the small intestine, α-glucosidase mediates the hydrolysis of polysaccharides into monosaccharides which cause a spike in blood glucose levels. Therefore, inhibitors of α-glucosidase can reduce the rate of polysaccharides breakdown, reduce of glucose absorption, and provide antidiabetic effects. Schiff bases derived from a primary amine and carbonyl compound involving an aldehyde or a ketone, are a well-known group of organic compounds with a broad range of biological activities including antidiabetic activity. The current study emphasizes the molecular structure of various synthesized Schiff base-containing compounds and the structure-activity relationship of the most active compounds that serve as α-glucosidase inhibitors. We believe this review will provide valuable information for those developing Schiff base compounds with antidiabetic activity.</p><p></p>

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A glance into Schiff-based α-glucosidase inhibitors in medicinal chemistry

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Sakineh Dadashpour

摘要

Diabetes mellitus is a chronic disorder characterized by hyperglycemia and is caused by metabolic dysregulation. According to a report from the World Health Organization (WHO), in 2014, more than 422 million people in the world were diagnosed with diabetes. In the small intestine, α-glucosidase mediates the hydrolysis of polysaccharides into monosaccharides which cause a spike in blood glucose levels. Therefore, inhibitors of α-glucosidase can reduce the rate of polysaccharides breakdown, reduce of glucose absorption, and provide antidiabetic effects. Schiff bases derived from a primary amine and carbonyl compound involving an aldehyde or a ketone, are a well-known group of organic compounds with a broad range of biological activities including antidiabetic activity. The current study emphasizes the molecular structure of various synthesized Schiff base-containing compounds and the structure-activity relationship of the most active compounds that serve as α-glucosidase inhibitors. We believe this review will provide valuable information for those developing Schiff base compounds with antidiabetic activity.