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<p>To develop a structurally novel and efficient insecticide, a series of meta-diamide compounds incorporating <i>n</i>-propyl groups were designed and synthesized through active substructure splicing. This was achieved by using cyproflanilide as the lead compound while maintaining its fundamental active skeleton. All compounds were characterized by <sup>1</sup>H NMR, <sup>13</sup>C NMR, and HRMS. Preliminary bioassay results showed that some target compounds exhibited strong insecticidal activity against <i>Plutella xylostella</i>, <i>Mythimna separata</i>, and <i>Tetranychus cinnabarinus</i>. Notably, compound <b>7i</b> exhibited 100% lethality at a concentration of 1 mg/L against both <i>Plutella xylostella</i> and <i>Mythimna separata</i>; meanwhile, compound 7f achieved complete lethality against <i>Tetranychus cinnabarinus</i> at a concentration of 100 mg/L. These findings may provide valuable insights for developing novel, highly efficient meta-diamide compounds.</p><p></p>

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Design, synthesis and insecticidal activities of novel m-diamide compounds containing n-propyl group

  • 期刊论文

  • 发表日期：

    2025年1月21日

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  • Daoxin Wu,
  • Bingqing Li,
  • Jiyong Liu,
  • Tingting Zhao,
  • Juncheng Xiang,
  • Kangming Li

摘要

To develop a structurally novel and efficient insecticide, a series of meta-diamide compounds incorporating n-propyl groups were designed and synthesized through active substructure splicing. This was achieved by using cyproflanilide as the lead compound while maintaining its fundamental active skeleton. All compounds were characterized by 1H NMR, 13C NMR, and HRMS. Preliminary bioassay results showed that some target compounds exhibited strong insecticidal activity against Plutella xylostella, Mythimna separata, and Tetranychus cinnabarinus. Notably, compound 7i exhibited 100% lethality at a concentration of 1 mg/L against both Plutella xylostella and Mythimna separata; meanwhile, compound 7f achieved complete lethality against Tetranychus cinnabarinus at a concentration of 100 mg/L. These findings may provide valuable insights for developing novel, highly efficient meta-diamide compounds.