Scholarlink

<p>This study focuses on the design, synthesis, and evaluation of a series of salidroside derivatives (pOBZ-1~pOBZ-11) for their potential as inhibitors of monoamine oxidase B (MAO-B) and amyloid beta (Aβ<sub>42</sub>) aggregation, and neuroprotective agents. Among the synthesized derivatives, pOBZ-1 and pOBZ-2 exhibited superior MAO-B inhibitory activity compared to salidroside, with notable selectivity over MAO-A. These compounds demonstrated linear competitive inhibition. Additionally, the derivatives effectively inhibited Aβ<sub>42</sub> aggregation and protected SH-SY5Y cells from Aβ<sub>42</sub> and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced neurotoxicity. The findings suggest that pOBZ-2, in particular, holds promise as a therapeutic candidate for Alzheimer’s disease.</p> Graphical abstract <p></p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Design, synthesis, and neuroprotective activity of salidroside-based dual inhibitors of selective monoamine oxidase B and amyloid-β aggregation

  • 期刊论文

  • 发表日期：

    2025年1月2日

查看全文
  • Juan Zhang,
  • Kong-Kai Zhu,
  • Kai-Ming Wang,
  • Cheng-Shi Jiang

摘要

This study focuses on the design, synthesis, and evaluation of a series of salidroside derivatives (pOBZ-1~pOBZ-11) for their potential as inhibitors of monoamine oxidase B (MAO-B) and amyloid beta (Aβ42) aggregation, and neuroprotective agents. Among the synthesized derivatives, pOBZ-1 and pOBZ-2 exhibited superior MAO-B inhibitory activity compared to salidroside, with notable selectivity over MAO-A. These compounds demonstrated linear competitive inhibition. Additionally, the derivatives effectively inhibited Aβ42 aggregation and protected SH-SY5Y cells from Aβ42 and hydrogen peroxide (H2O2)-induced neurotoxicity. The findings suggest that pOBZ-2, in particular, holds promise as a therapeutic candidate for Alzheimer’s disease.

Graphical abstract