Quinazoline derivatives and hybrids: recent structures with potent bioactivity

Quinazolines represent a class of nitrogen-containing heterocyclics with a broad spectrum of biological applications. Many studies have explored the medicinal qualities of quinazoline derivatives, such as antitumor, antimicrobial, antiviral, anti-inflammatory, antioxidant, and antihyperglycemic effects. The structure-activity relationship of the quinazoline derivatives and hybrids, with selected examples of patented quinazoline-based drugs, was displayed. Quinazoline hybrid molecules containing different bioactive moieties are also presented and discussed. This article reviews the progress and development of quinazoline derivatives and hybrid molecules bearing a quinazoline pharmacophore in medicinal chemistry to provide synthetic and medicinal chemists with a detailed roadmap for further designs and development of more potent quinazoline-based drugs.