In this paper, we investigate a diffusive susceptible-infected-susceptible (SIS) epidemic model with a mass action infection mechanism on an evolving domain. The model incorporates logistic population growth for susceptible individuals and the evolution of the time-varying domain is governed by a scaling function \(\rho (t)\) . We establish the global existence and uniform boundedness of solutions to the system. Furthermore, we define the basic reproduction number \(\mathcal {R}_{0}\) , which relies on the evolution rate of the domain, the diffusion coefficient of the infected populations, etc. We show that the disease-free equilibrium (DFE) is globally stable if \(\mathcal {R}_{0}< 1\) , whereas an endemic equilibrium (EE) exists and is globally stable for \(\mathcal {R}_{0}> 1\) in homogeneous environments. We also analyze the asymptotic profiles of the EE for large and small diffusion rates of the susceptible and infected populations. Our numerical results for the specific scaling function \(\rho (t) = 1+ (\rho _\infty - 1)(1 - e^{-\alpha ^* t})\) indicate that domain expansion may hinder disease elimination compared to fixed domains.