In this paper, we study a chemotaxis system with indirect signal production/consumption and signal-dependent motility under homogeneous Neumann boundary conditions in a smoothly bounded domain \(\Omega \subset \mathbb {R}^n\) , which described as \(u_t=\Delta (\gamma (v)u)\) , \(v_t=d_v\Delta v+f(v,w)\) , \(w_t=d_w\Delta w-w+u\) . If \(f(v,w)=-v+w\) and the motility function satisfies \(\gamma \in C^3((0,\infty ))\) , \(\gamma (s)>0\) for \(s>0\) , we proved that the system admits a global classical solution for any appropriately regular initial value when \(n\le 3\) , and further, if we exclude the singular at \(s=0\) , then the global smooth solution is bounded-in-time. While if \(f(v,w)=-vw\) and \(\gamma \in C^3([0,\infty ))\) , \(\gamma >0\) on \([0,\infty )\) , we showed the existence and asymptotic behavior of globally bounded solutions when either \(n\le 5\) or \(\Vert v_0\Vert _{L^\infty (\Omega )}\) is suitably small.