In this paper, we study the following biharmonic Choquard-type problem \(\begin{aligned} \begin{aligned} \left\{ \begin{array}{ll} \Delta ^2u-\beta \Delta u=\lambda u+(I_\mu *F(u))f(u), \quad \text{ in }\ \ \mathbb {R}^4,\\ \displaystyle \int \limits _{\mathbb {R}^4}|u|^2\textrm{d}x=c^2>0,\quad u\in H^2(\mathbb {R}^4), \end{array} \right. \end{aligned} \end{aligned}\) where \(\beta \ge 0\) , \(\lambda \in \mathbb {R}\) , \(I_\mu =\frac{1}{|x|^\mu }\) with \(\mu \in (0,4)\) , F(u) is the primitive function of f(u), and f is a continuous function with exponential critical growth. By using the mountain-pass argument, we prove the existence of radial ground-state solutions for the above problem.