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Boundedness and large-time behavior in a chemotaxis system with signal-dependent motility arising from tumor invasion

  • Dan Li

摘要

In this paper, we study the following chemotaxis system with signal-dependent motility arising from tumor invasion \(\begin{aligned} \left\{ \begin{aligned}&u_t=\Delta (\varphi (v)u)+\rho u -\mu u^l,&\qquad \quad x\in \Omega ,\,t>0,\\&v_t=\Delta v+ wz,&\qquad \quad x\in \Omega ,\,t>0,\\&w_t=-wz,&\qquad \quad x\in \Omega ,\,t>0,\\&z_t=\Delta z-z+u,&\qquad \quad x\in \Omega ,\,t>0 \end{aligned} \right. \end{aligned}\) u t = Δ ( φ ( v ) u ) + ρ u - μ u l , x Ω , t > 0 , v t = Δ v + w z , x Ω , t > 0 , w t = - w z , x Ω , t > 0 , z t = Δ z - z + u , x Ω , t > 0 under homogeneous Neumann boundary conditions in a smooth bounded domain \( \Omega \subset {\mathbb {R}}^n(n\ge 1)\) Ω R n ( n 1 ) , where the parameters \( \rho \ge 0,\mu \ge 0\) ρ 0 , μ 0 and \( l>1\) l > 1 are constants, the motility function \(\varphi (v)\) φ ( v ) satisfies \( \varphi (v)\in C^3([0,+\infty )), \varphi _1\le \varphi (v)\le \varphi _2\) φ ( v ) C 3 ( [ 0 , + ) ) , φ 1 φ ( v ) φ 2 and \(|\varphi '(v)|\le \varphi _3\) | φ ( v ) | φ 3 with \(\varphi _1,\varphi _2,\varphi _3>0.\) φ 1 , φ 2 , φ 3 > 0 . The purpose of this paper is to prove that the existence of global bounded solution for \(1\le n\le 3\) 1 n 3 . For \(n\ge 4\) n 4 , we prove that the nonnegative classical solution (uvwz) is globally bounded if \(l>\frac{n}{2}\) l > n 2 . In addition, we also show that all the global bounded solution will converge to the non-trivial constant steady state exponentially.