Let \(A\) be an affine factorial domain over a field \(K\) of characteristic zero endowed with an irreducible locally nilpotent derivation \(\xi \) . Assume that \(\xi \) has the freeness property, its kernel is affine over \(K\) and its plinth ideal is generated by a power of a prime element in \(\ker (\xi )\) . The main result of this paper asserts that the differential algebra \((A,\xi )\) is \(K\) -isomorphic to the coordinate ring of a generalized Danielewski variety endowed with a Jacobian-type derivation.