<p>In this paper, we deal with the following Neumann-initial boundary value problem for a quasilinear chemotaxis model describing tumor angiogenesis: <Equation ID="Equ104"> <EquationSource Format="TEX">\( {\left\{ \begin{array}{ll} u_t = \nabla \cdot (D(u)\nabla u) - \chi \nabla \cdot (u\nabla v) + \xi _1\nabla \cdot (u^m\nabla w) , &amp; x\in \Omega ,\ t&gt; 0, \\ v_t = \Delta v + \xi _2\nabla \cdot (v\nabla w) - v + u, &amp; x\in \Omega ,\ t&gt; 0, \\ 0 = \Delta w - w + u, &amp; x\in \Omega ,\ t&gt; 0, \\ {\frac{\partial u}{\partial \nu } = \frac{\partial v}{\partial \nu } = \frac{\partial w}{\partial \nu } = 0, }&amp; {x\in \partial \Omega ,\ t &gt; 0, }\\ {u(x,0) = u_0(x),\ v(x,0) = v_0(x),} &amp; { x\in \Omega ,} \end{array}\right. } \)</EquationSource> <EquationSource Format="MATHML"><math display="block"> <mfenced open="{"> <mrow> <mtable> <mtr> <mtd columnalign="left"> <mrow> <msub> <mi>u</mi> <mi>t</mi> </msub> <mo>=</mo> <mi mathvariant="normal">∇</mi> <mo>·</mo> <mrow> <mo stretchy="false">(</mo> <mi>D</mi> <mrow> <mo stretchy="false">(</mo> <mi>u</mi> <mo stretchy="false">)</mo> </mrow> <mi mathvariant="normal">∇</mi> <mi>u</mi> <mo stretchy="false">)</mo> </mrow> <mo>-</mo> <mi>χ</mi> <mi mathvariant="normal">∇</mi> <mo>·</mo> <mrow> <mo stretchy="false">(</mo> <mi>u</mi> <mi mathvariant="normal">∇</mi> <mi>v</mi> <mo stretchy="false">)</mo> </mrow> <mo>+</mo> <msub> <mi>ξ</mi> <mn>1</mn> </msub> <mi mathvariant="normal">∇</mi> <mo>·</mo> <mrow> <mo stretchy="false">(</mo> <msup> <mi>u</mi> <mi>m</mi> </msup> <mi mathvariant="normal">∇</mi> <mi>w</mi> <mo stretchy="false">)</mo> </mrow> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mspace width="4pt" /> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <msub> <mi>v</mi> <mi>t</mi> </msub> <mo>=</mo> <mi mathvariant="normal">Δ</mi> <mi>v</mi> <mo>+</mo> <msub> <mi>ξ</mi> <mn>2</mn> </msub> <mi mathvariant="normal">∇</mi> <mo>·</mo> <mrow> <mo stretchy="false">(</mo> <mi>v</mi> <mi mathvariant="normal">∇</mi> <mi>w</mi> <mo stretchy="false">)</mo> </mrow> <mo>-</mo> <mi>v</mi> <mo>+</mo> <mi>u</mi> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mspace width="4pt" /> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <mn>0</mn> <mo>=</mo> <mi mathvariant="normal">Δ</mi> <mi>w</mi> <mo>-</mo> <mi>w</mi> <mo>+</mo> <mi>u</mi> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mspace width="4pt" /> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <mrow> <mfrac> <mrow> <mi>∂</mi> <mi>u</mi> </mrow> <mrow> <mi>∂</mi> <mi>ν</mi> </mrow> </mfrac> <mo>=</mo> <mfrac> <mrow> <mi>∂</mi> <mi>v</mi> </mrow> <mrow> <mi>∂</mi> <mi>ν</mi> </mrow> </mfrac> <mo>=</mo> <mfrac> <mrow> <mi>∂</mi> <mi>w</mi> </mrow> <mrow> <mi>∂</mi> <mi>ν</mi> </mrow> </mfrac> <mo>=</mo> <mn>0</mn> <mo>,</mo> </mrow> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mi>x</mi> <mo>∈</mo> <mi>∂</mi> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mspace width="4pt" /> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <mrow> <mi>u</mi> <mrow> <mo stretchy="false">(</mo> <mi>x</mi> <mo>,</mo> <mn>0</mn> <mo stretchy="false">)</mo> </mrow> <mo>=</mo> <msub> <mi>u</mi> <mn>0</mn> </msub> <mrow> <mo stretchy="false">(</mo> <mi>x</mi> <mo stretchy="false">)</mo> </mrow> <mo>,</mo> <mspace width="4pt" /> <mi>v</mi> <mrow> <mo stretchy="false">(</mo> <mi>x</mi> <mo>,</mo> <mn>0</mn> <mo stretchy="false">)</mo> </mrow> <mo>=</mo> <msub> <mi>v</mi> <mn>0</mn> </msub> <mrow> <mo stretchy="false">(</mo> <mi>x</mi> <mo stretchy="false">)</mo> </mrow> <mo>,</mo> </mrow> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> </mrow> </mtd> </mtr> </mtable> </mrow> </mfenced> </math></EquationSource> </Equation>in a bounded smooth domain <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\Omega \subset \mathbb {R}^n (n\le 3)\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi mathvariant="normal">Ω</mi> <mo>⊂</mo> <msup> <mrow> <mi mathvariant="double-struck">R</mi> </mrow> <mi>n</mi> </msup> <mrow> <mo stretchy="false">(</mo> <mi>n</mi> <mo>≤</mo> <mn>3</mn> <mo stretchy="false">)</mo> </mrow> </mrow> </math></EquationSource> </InlineEquation>, where the parameter <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(\chi , \xi _1,\xi _2 &gt; 0\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>χ</mi> <mo>,</mo> <msub> <mi>ξ</mi> <mn>1</mn> </msub> <mo>,</mo> <msub> <mi>ξ</mi> <mn>2</mn> </msub> <mo>&gt;</mo> <mn>0</mn> </mrow> </math></EquationSource> </InlineEquation>, <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(D(u)\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>D</mi> <mo stretchy="false">(</mo> <mi>u</mi> <mo stretchy="false">)</mo> </mrow> </math></EquationSource> </InlineEquation> is supposed to satisfy the following property <Equation ID="Equ105"> <EquationSource Format="TEX">\( D(u) \ge (u + 1)^\alpha \text { with } \alpha &gt; 0. \)</EquationSource> <EquationSource Format="MATHML"><math display="block"> <mrow> <mi>D</mi> <mrow> <mo stretchy="false">(</mo> <mi>u</mi> <mo stretchy="false">)</mo> </mrow> <mo>≥</mo> <msup> <mrow> <mo stretchy="false">(</mo> <mi>u</mi> <mo>+</mo> <mn>1</mn> <mo stretchy="false">)</mo> </mrow> <mi>α</mi> </msup> <mspace width="0.333333em" /> <mtext>with</mtext> <mspace width="0.333333em" /> <mi>α</mi> <mo>&gt;</mo> <mn>0</mn> <mo>.</mo> </mrow> </math></EquationSource> </Equation>Assume that <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\(\xi _1\ge \lambda _1^*\chi ^2\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mi>ξ</mi> <mn>1</mn> </msub> <mo>≥</mo> <msubsup> <mi>λ</mi> <mn>1</mn> <mo>∗</mo> </msubsup> <msup> <mi>χ</mi> <mn>2</mn> </msup> </mrow> </math></EquationSource> </InlineEquation>, where the parameter <InlineEquation ID="IEq5"> <EquationSource Format="TEX">\(\lambda _1^* = \lambda _1^*(u_0, v_0, \Omega ) &gt; 0\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msubsup> <mi>λ</mi> <mn>1</mn> <mo>∗</mo> </msubsup> <mo>=</mo> <msubsup> <mi>λ</mi> <mn>1</mn> <mo>∗</mo> </msubsup> <mrow> <mo stretchy="false">(</mo> <msub> <mi>u</mi> <mn>0</mn> </msub> <mo>,</mo> <msub> <mi>v</mi> <mn>0</mn> </msub> <mo>,</mo> <mi mathvariant="normal">Ω</mi> <mo stretchy="false">)</mo> </mrow> <mo>&gt;</mo> <mn>0</mn> </mrow> </math></EquationSource> </InlineEquation>; then the system admits a global classical solution (<i>u</i>,&#xa0;<i>v</i>,&#xa0;<i>w</i>) via subtle energy estimates. Moreover, it is asserted that the corresponding solution exponentially converges to the constant stationary solution <InlineEquation ID="IEq6"> <EquationSource Format="TEX">\((\bar{u}_0, \bar{u}_0, \bar{u}_0)\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mo stretchy="false">(</mo> <msub> <mover accent="true"> <mrow> <mi>u</mi> </mrow> <mrow> <mo stretchy="false">¯</mo> </mrow> </mover> <mn>0</mn> </msub> <mo>,</mo> <msub> <mover accent="true"> <mrow> <mi>u</mi> </mrow> <mrow> <mo stretchy="false">¯</mo> </mrow> </mover> <mn>0</mn> </msub> <mo>,</mo> <msub> <mover accent="true"> <mrow> <mi>u</mi> </mrow> <mrow> <mo stretchy="false">¯</mo> </mrow> </mover> <mn>0</mn> </msub> <mo stretchy="false">)</mo> </mrow> </math></EquationSource> </InlineEquation> provided the initial data <InlineEquation ID="IEq7"> <EquationSource Format="TEX">\(u_0\)</EquationSource> <EquationSource Format="MATHML"><math> <msub> <mi>u</mi> <mn>0</mn> </msub> </math></EquationSource> </InlineEquation> is sufficiently small, where <InlineEquation ID="IEq8"> <EquationSource Format="TEX">\(\bar{u}_0 = \frac{\int _\Omega u_0}{|\Omega |}\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <msub> <mover accent="true"> <mrow> <mi>u</mi> </mrow> <mrow> <mo stretchy="false">¯</mo> </mrow> </mover> <mn>0</mn> </msub> <mo>=</mo> <mfrac> <mrow> <msub> <mo>∫</mo> <mi mathvariant="normal">Ω</mi> </msub> <msub> <mi>u</mi> <mn>0</mn> </msub> </mrow> <mrow> <mo stretchy="false">|</mo> <mi mathvariant="normal">Ω</mi> <mo stretchy="false">|</mo> </mrow> </mfrac> </mrow> </math></EquationSource> </InlineEquation>.</p>

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Global boundedness in a quasilinear chemotaxis model for tumor angiogenesis

  • Mingxin Xiao,
  • Chun Wu

摘要

In this paper, we deal with the following Neumann-initial boundary value problem for a quasilinear chemotaxis model describing tumor angiogenesis: \( {\left\{ \begin{array}{ll} u_t = \nabla \cdot (D(u)\nabla u) - \chi \nabla \cdot (u\nabla v) + \xi _1\nabla \cdot (u^m\nabla w) , & x\in \Omega ,\ t> 0, \\ v_t = \Delta v + \xi _2\nabla \cdot (v\nabla w) - v + u, & x\in \Omega ,\ t> 0, \\ 0 = \Delta w - w + u, & x\in \Omega ,\ t> 0, \\ {\frac{\partial u}{\partial \nu } = \frac{\partial v}{\partial \nu } = \frac{\partial w}{\partial \nu } = 0, }& {x\in \partial \Omega ,\ t > 0, }\\ {u(x,0) = u_0(x),\ v(x,0) = v_0(x),} & { x\in \Omega ,} \end{array}\right. } \) u t = · ( D ( u ) u ) - χ · ( u v ) + ξ 1 · ( u m w ) , x Ω , t > 0 , v t = Δ v + ξ 2 · ( v w ) - v + u , x Ω , t > 0 , 0 = Δ w - w + u , x Ω , t > 0 , u ν = v ν = w ν = 0 , x Ω , t > 0 , u ( x , 0 ) = u 0 ( x ) , v ( x , 0 ) = v 0 ( x ) , x Ω , in a bounded smooth domain \(\Omega \subset \mathbb {R}^n (n\le 3)\) Ω R n ( n 3 ) , where the parameter \(\chi , \xi _1,\xi _2 > 0\) χ , ξ 1 , ξ 2 > 0 , \(D(u)\) D ( u ) is supposed to satisfy the following property \( D(u) \ge (u + 1)^\alpha \text { with } \alpha > 0. \) D ( u ) ( u + 1 ) α with α > 0 . Assume that \(\xi _1\ge \lambda _1^*\chi ^2\) ξ 1 λ 1 χ 2 , where the parameter \(\lambda _1^* = \lambda _1^*(u_0, v_0, \Omega ) > 0\) λ 1 = λ 1 ( u 0 , v 0 , Ω ) > 0 ; then the system admits a global classical solution (uvw) via subtle energy estimates. Moreover, it is asserted that the corresponding solution exponentially converges to the constant stationary solution \((\bar{u}_0, \bar{u}_0, \bar{u}_0)\) ( u ¯ 0 , u ¯ 0 , u ¯ 0 ) provided the initial data \(u_0\) u 0 is sufficiently small, where \(\bar{u}_0 = \frac{\int _\Omega u_0}{|\Omega |}\) u ¯ 0 = Ω u 0 | Ω | .