<p>This paper establishes the global existence and boundedness of classical solutions for a parabolic-elliptic chemotaxis system coupled with nonlinear reaction dynamics, which models key aspects of tumor-immune evasion interactions. The model under consideration is given by: <Equation ID="Equ73"> <EquationSource Format="TEX">\(\begin{aligned} {\left\{ \begin{array}{ll} u_{t}=\Delta u-\nabla \cdot (u\nabla v)+\mu u-\mu u^r,&amp; \quad x\in \Omega ,t&gt;0,\\ 0=\Delta v-v+w,&amp; \quad x\in \Omega ,t&gt;0,\\ w_{t}=auz-w,&amp; \quad x\in \Omega ,t&gt;0,\\ z_{t}=\Delta z-uz+w,&amp; \quad x\in \Omega ,t&gt;0 \end{array}\right. } \end{aligned}\)</EquationSource> <EquationSource Format="MATHML"><math display="block"> <mrow> <mtable> <mtr> <mtd columnalign="right"> <mfenced open="{"> <mrow> <mtable> <mtr> <mtd columnalign="left"> <mrow> <msub> <mi>u</mi> <mi>t</mi> </msub> <mo>=</mo> <mi mathvariant="normal">Δ</mi> <mi>u</mi> <mo>-</mo> <mi mathvariant="normal">∇</mi> <mo>·</mo> <mrow> <mo stretchy="false">(</mo> <mi>u</mi> <mi mathvariant="normal">∇</mi> <mi>v</mi> <mo stretchy="false">)</mo> </mrow> <mo>+</mo> <mi>μ</mi> <mi>u</mi> <mo>-</mo> <mi>μ</mi> <msup> <mi>u</mi> <mi>r</mi> </msup> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mspace width="1em" /> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <mn>0</mn> <mo>=</mo> <mi mathvariant="normal">Δ</mi> <mi>v</mi> <mo>-</mo> <mi>v</mi> <mo>+</mo> <mi>w</mi> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mspace width="1em" /> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <msub> <mi>w</mi> <mi>t</mi> </msub> <mo>=</mo> <mi>a</mi> <mi>u</mi> <mi>z</mi> <mo>-</mo> <mi>w</mi> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mspace width="1em" /> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> <mo>,</mo> </mrow> </mtd> </mtr> <mtr> <mtd columnalign="left"> <mrow> <mrow /> <msub> <mi>z</mi> <mi>t</mi> </msub> <mo>=</mo> <mi mathvariant="normal">Δ</mi> <mi>z</mi> <mo>-</mo> <mi>u</mi> <mi>z</mi> <mo>+</mo> <mi>w</mi> <mo>,</mo> </mrow> </mtd> <mtd columnalign="left"> <mrow> <mspace width="1em" /> <mi>x</mi> <mo>∈</mo> <mi mathvariant="normal">Ω</mi> <mo>,</mo> <mi>t</mi> <mo>&gt;</mo> <mn>0</mn> </mrow> </mtd> </mtr> </mtable> </mrow> </mfenced> </mtd> </mtr> </mtable> </mrow> </math></EquationSource> </Equation>subject to no-flux boundary conditions in a bounded domain <InlineEquation ID="IEq1"> <EquationSource Format="TEX">\(\Omega \subset \mathbb {R}^N(N\ge 2)\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi mathvariant="normal">Ω</mi> <mo>⊂</mo> <msup> <mrow> <mi mathvariant="double-struck">R</mi> </mrow> <mi>N</mi> </msup> <mrow> <mo stretchy="false">(</mo> <mi>N</mi> <mo>≥</mo> <mn>2</mn> <mo stretchy="false">)</mo> </mrow> </mrow> </math></EquationSource> </InlineEquation>, where <InlineEquation ID="IEq2"> <EquationSource Format="TEX">\(r&gt;1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>r</mi> <mo>&gt;</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation>, <InlineEquation ID="IEq3"> <EquationSource Format="TEX">\(0&lt;a\le 1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mn>0</mn> <mo>&lt;</mo> <mi>a</mi> <mo>≤</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation> and <InlineEquation ID="IEq4"> <EquationSource Format="TEX">\(\mu &gt;0\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>μ</mi> <mo>&gt;</mo> <mn>0</mn> </mrow> </math></EquationSource> </InlineEquation>. The main result demonstrates that bounded global classical solutions exist under the following parameter constraints: (i) For <InlineEquation ID="IEq5"> <EquationSource Format="TEX">\(N = 2\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>N</mi> <mo>=</mo> <mn>2</mn> </mrow> </math></EquationSource> </InlineEquation>, with <InlineEquation ID="IEq6"> <EquationSource Format="TEX">\(r &gt; 1\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>r</mi> <mo>&gt;</mo> <mn>1</mn> </mrow> </math></EquationSource> </InlineEquation>; (ii) For <InlineEquation ID="IEq7"> <EquationSource Format="TEX">\(N \ge 3\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>N</mi> <mo>≥</mo> <mn>3</mn> </mrow> </math></EquationSource> </InlineEquation>, with <InlineEquation ID="IEq8"> <EquationSource Format="TEX">\(r &gt; 1 + \frac{N}{2}\)</EquationSource> <EquationSource Format="MATHML"><math> <mrow> <mi>r</mi> <mo>&gt;</mo> <mn>1</mn> <mo>+</mo> <mfrac> <mi>N</mi> <mn>2</mn> </mfrac> </mrow> </math></EquationSource> </InlineEquation>.</p>

错误:搜索内容不能为空,请输入英文关键词
错误:关键词超出字数限制,请精简
高级检索

Global existence and boundedness in a tumor-immune evasion model incorporating logistic growth and chemotactic migration

  • Cunsai Shen,
  • Jiashan Zheng,
  • Liqiong Pu

摘要

This paper establishes the global existence and boundedness of classical solutions for a parabolic-elliptic chemotaxis system coupled with nonlinear reaction dynamics, which models key aspects of tumor-immune evasion interactions. The model under consideration is given by: \(\begin{aligned} {\left\{ \begin{array}{ll} u_{t}=\Delta u-\nabla \cdot (u\nabla v)+\mu u-\mu u^r,& \quad x\in \Omega ,t>0,\\ 0=\Delta v-v+w,& \quad x\in \Omega ,t>0,\\ w_{t}=auz-w,& \quad x\in \Omega ,t>0,\\ z_{t}=\Delta z-uz+w,& \quad x\in \Omega ,t>0 \end{array}\right. } \end{aligned}\) u t = Δ u - · ( u v ) + μ u - μ u r , x Ω , t > 0 , 0 = Δ v - v + w , x Ω , t > 0 , w t = a u z - w , x Ω , t > 0 , z t = Δ z - u z + w , x Ω , t > 0 subject to no-flux boundary conditions in a bounded domain \(\Omega \subset \mathbb {R}^N(N\ge 2)\) Ω R N ( N 2 ) , where \(r>1\) r > 1 , \(0<a\le 1\) 0 < a 1 and \(\mu >0\) μ > 0 . The main result demonstrates that bounded global classical solutions exist under the following parameter constraints: (i) For \(N = 2\) N = 2 , with \(r > 1\) r > 1 ; (ii) For \(N \ge 3\) N 3 , with \(r > 1 + \frac{N}{2}\) r > 1 + N 2 .