Scholarlink

<p>The escalating crisis of antimicrobial resistance (AMR) poses a significant threat to global human and animal health. River systems, being highly susceptible to anthropogenic influences, are considered critical reservoirs and dissemination pathways for antibiotic resistance genes (ARGs). However, a comprehensive understanding of the distribution and dynamics of ARGs in large riverine ecosystems remains limited. Here, we conducted high-throughput profiling of ARGs along the Yangtze River in China. Our analysis identified a total of 34 ARG subtypes, encompassing 13 major types, prevalent in both freshwater (FW) and freshwater sediment (FWS) samples. ARG abundance was substantially higher in freshwater than in sediment samples, and ARG composition also differed significantly between these two compartments. In contrast, no significant differences in either abundance or composition were observed between upstream and middle–downstream sections. Strong correlations were detected between ARGs and mobile genetic elements (MGEs), and network analysis revealed complex cooccurrence patterns among different ARG types. Notably, ARG α-diversity differed significantly between sites upstream and downstream of the Three Gorges Dam (TGD), whereas β-diversity remained unchanged. This study provides insights into the resistome of large river systems and will inform future strategies for monitoring and mitigating ARG risks in aquatic environments.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Insights into the distribution of the antibiotic resistome in China’s Yangtze River

  • 期刊论文

  • 发表日期：

    2026年7月31日

查看全文
  • Kang Zhou,
  • Yunhui He

摘要

The escalating crisis of antimicrobial resistance (AMR) poses a significant threat to global human and animal health. River systems, being highly susceptible to anthropogenic influences, are considered critical reservoirs and dissemination pathways for antibiotic resistance genes (ARGs). However, a comprehensive understanding of the distribution and dynamics of ARGs in large riverine ecosystems remains limited. Here, we conducted high-throughput profiling of ARGs along the Yangtze River in China. Our analysis identified a total of 34 ARG subtypes, encompassing 13 major types, prevalent in both freshwater (FW) and freshwater sediment (FWS) samples. ARG abundance was substantially higher in freshwater than in sediment samples, and ARG composition also differed significantly between these two compartments. In contrast, no significant differences in either abundance or composition were observed between upstream and middle–downstream sections. Strong correlations were detected between ARGs and mobile genetic elements (MGEs), and network analysis revealed complex cooccurrence patterns among different ARG types. Notably, ARG α-diversity differed significantly between sites upstream and downstream of the Three Gorges Dam (TGD), whereas β-diversity remained unchanged. This study provides insights into the resistome of large river systems and will inform future strategies for monitoring and mitigating ARG risks in aquatic environments.