We study the existence of solution to the system of differential equations \((\phi (u'))'=f(t,u,u')\) with nonlinear boundary conditions \(\begin{aligned} g(u(0),u,u')=0, \quad h(u'(1),u,u')=0, \end{aligned}\) where \(f:[0,1]\times \mathbb {R}^{n}\times \mathbb {R}^{n}\rightarrow \mathbb {R}^{n}\) , \(g,h:\mathbb {R}^{n}\times C([0,1],\mathbb {R}^{n})\times C([0,1],\mathbb {R}^{n})\rightarrow \mathbb {R}^{n}\) are continuous, \(\phi :\prod _{i=1}^{n}(-a_i,a_i) \rightarrow \mathbb {R}^{n}\) , \(0<a_i\le +\infty \) , \(\phi (s)=\left( \phi _1(s_1),\dots ,\phi _n(s_n)\right) \) and \(\phi _i:(-a_i,a_i)\rightarrow \mathbb {R}\) is a one dimensional regular or singular homeomorphism. Our proofs are based on the concept of the lower and upper solutions.