In this paper, we completely describe the closed range of bounded weighted composition operator on the quaternionic Fock space \(\mathcal {F}^2(\mathbb {H})\) . This result further facilitates the characterizations for \(C_{f, \varphi }\) or \(C_{f, \varphi }^*\) preserving frames, Riesz bases or tight frames on \(\mathcal {F}^2(\mathbb {H})\) . Especially, we creatively obtain a useful formula of the adjoint operator \(C_{f, \varphi }^*\) on \(\mathcal {F}^2(\mathbb {H})\) , which is crucial for showing the equivalence of the unitary, isometry and co-isometry of the weighted composition operator on \(\mathcal {F}^2(\mathbb {H})\) . This result is new even on the ordinary complex Fock space. Moreover, a series of new equivalent characterizations for quaternionic composition operators on \(\mathcal {F}^2(\mathbb {H})\) follow as a special case.