We introduce the Zak transform on \(L^{2}(\mathbb {R}^{2n})\) associated with the Weyl transform. By making use of this transform, we define a bracket map and prove that the system of twisted translates \(\{{T_{(k,l)}^t}{\phi }: k,l\in \mathbb {Z}^{n}\}\) is a frame sequence iff \(0<A\le \left[ {\phi },{\phi }\right] (\xi ,\xi ^{'})\le B<\infty ,\) for a.e \((\xi ,\xi ^{'})\in \Omega _{{\phi }},\) where \(\Omega _{{\phi }}=\{({\xi },{\xi ^{'}})\in {\mathbb {T}^{n}}\times {\mathbb {T}^{n}}: \left[ {\phi },{\phi }\right] (\xi ,\xi ^{'})\ne 0\}\) . We also prove a similar result for the system \(\{{T_{(k,l)}^t}{\phi }: k,l\in \mathbb {Z}^{n}\}\) to be a Riesz sequence. For a given function belonging to the principal twisted shift-invariant space \(V^{t}({\phi })\) , we find a necessary and sufficient condition for the existence of a canonical biorthogonal function. Further, we obtain a characterization for the system \(\{{T_{(k,l)}^t}{\phi }: k,l\in \mathbb {Z}\}\) to be a Schauder basis for \(V^{t}({\phi })\) in terms of a Muckenhoupt \(\mathcal {A}_{2}\) weight function.