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<p>Achieving better clinical outcomes in cancer research requires a deeper understanding of tumoral biology and the application of this knowledge within a clinic setting. The aim of this review is to briefly summarize the current knowledge on H<sub>3</sub>R molecular pharmacology, the clinical use of H<sub>3</sub>R antagonists, and the most recent findings reporting H<sub>3</sub>R role in cancer biology. We will discuss in detail the current landscape and clinical perspectives of the modulation of this H<sub>3</sub>R on cancer progression and treatment. We propose H<sub>3</sub>R as a promising molecular target for cancer drug repurposing and development.</p>

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Histamine H3 receptor: an emerging target for cancer therapy?

  • 期刊论文

  • 发表日期：

    2025年6月30日

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  • Paolo Lauretta,
  • Rocio Martinez Vivot,
  • Agueda Velazco,
  • Vanina A. Medina

摘要

Achieving better clinical outcomes in cancer research requires a deeper understanding of tumoral biology and the application of this knowledge within a clinic setting. The aim of this review is to briefly summarize the current knowledge on H3R molecular pharmacology, the clinical use of H3R antagonists, and the most recent findings reporting H3R role in cancer biology. We will discuss in detail the current landscape and clinical perspectives of the modulation of this H3R on cancer progression and treatment. We propose H3R as a promising molecular target for cancer drug repurposing and development.