Let G be a nontrivial connected graph and let \(d_G(u,v)\) be the distance between the vertices u and v in G. Let \(\mathcal{I}\mathcal{D}(G)\) be the set of independent dominating sets of G. A set \(I\in \mathcal{I}\mathcal{D}(G)\) is an independent semitotal dominating set of G if for every vertex \(v\in I\) there exists a vertex \(u\in I\setminus \{v\}\) such that \(d_G(u,v)=2\) . The independent semitotal domination number of a non-complete graph G is the minimum cardinality among all independent semitotal dominating sets of G. In this article, we establish tight bounds and derive closed formulas for the independent semitotal domination number of lexicographic product graphs \(G\circ H\) , expressed in terms of invariants of the factor graphs G and H.