Here, a weighted anisotropic p-Laplace equation \(\begin{aligned} -\Delta _{a\overrightarrow{p}}u+V(x)|x|^{-ap^*}|u|^{p^+-2}u=f(u), \end{aligned}\) in \(\mathbb {R}^N\) is considered where \(\Delta _{a\overrightarrow{p}}u:=\sum _{i=1}^N\frac{\partial }{\partial x_i}\left( |x|^{-ap_i} \left| \frac{\partial u}{\partial x_i}\right| ^{p_i-2}\frac{\partial u}{\partial x_i}\right) \) , the potential V can vanish at infinity with exponential decay, f is a function with subcritical growth of class \(C^1\) , \(\overrightarrow{p}=(p_1,\dots , p_N)\) , \(p^+=\max _{1\le i\le N}p_i\) and \(p^*=\frac{Np^+}{N-p^+}\) . Because of the lack of compactness, it is necessary to apply Del Pino and Felmer’s arguments and the Moser iteration method to study the existence and properties of a positive solution.