<p>We propose a scenario to produce large primordial lepton flavor asymmetries with vanishing total lepton asymmetry, based on the Affleck-Dine mechanism with Q-ball formation. This scenario can produce large lepton flavor asymmetries while automatically maintaining the vanishing total lepton number without fine-tuning, evading the current BBN and the CMB constraints by neutrino oscillations at MeV temperature. The asymmetries can be produced at cosmic temperatures of <i>T</i> ≳ 1 GeV, early enough to have broad impacts from the early Universe to the present cosmology. This scenario could affect various aspects of early Universe cosmology simultaneously or separately: (i) explaining the observed baryon asymmetry by the same origin as the lepton flavor asymmetries, (ii) affecting the nature of the QCD transition, (iii) opening up a new parameter space of sterile neutrino dark matter by enhancing their production, and (iv) altering the abundance of the light elements, in particular, resolving the recently reported helium-4 anomaly.</p>